Carly Lewis cautious over Bolt success
But United States (also known as USA) athlete, Lewis said: "When people ask me about Bolt I say he could be the greatest athlete of all time.
"But to run 10.03 seconds one year and 9.69 the next, if you don't question that in a sport with the reputation it has right now, you're a fool. Period."
Jamaican Bolt, 22, became the first man to win the 100m, 200m and 4x100m at a single Olympics since Lewis himself achieved the feat at the 1984 Los Angeles Games.
He is also the first man to set world records in all three events at a single Games.
But Lewis, who himself failed three drugs tests in 1988 only to be cleared of any intentional wrongdoing, believes it necessary to remain cautious about Bolt's incredible performances.
The 47-year-old told Sports Illustrated: "I'm proud of America right now because we have the best random and most comprehensive drug-testing programme.
"Countries like Jamaica do not have a random programme, so they can go months without being tested.
"No-one is accusing Bolt, but don't live by a different rule and expect the same kind of respect. How dare anybody feel that there shouldn't be scrutiny, especially in our sport?"